Phytochemical screening and antimicrobial activity of different solvent extracts of the aerial parts of Ethulia conyzoides

Israel Okoro, Helen Kadiri, Edith Okoro

Abstract


Ethulia conyzoides is a plant that is used in traditional medicine for the treatment of cancer, abdominal disorder and as an antihelminthic agent. To evaluate the scientific basis for the use of the plant, the chemical constituents of extracts of the aerial part and its antimicrobial activities were evaluated. The phytochemical constituents of acetone, ethanol and petroleum ether solvents extracts of the aerial parts of the plant were determined. Also, the antimicrobial activity of the concentrated extracts was evaluated by determining the diameter of zone of inhibition against Gram positive and Gram negative bacteria isolates using paper disc diffusion method. Results of the phytochemical studies revealed the presence of carbohydrate, cardiac glycoside, steroids and flavonoids in the petroleum ether extract, while carbohydrate, cardiac glycoside, alkaloids, steroids, triterpene, tannins and flavonoids were present in the acetone extract. The extracts were active against the tested organisms (Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Clostridium botulinum, Escherichia coli, Proteus mirabilis, Salmonella typhi  and Listeria monocytogenes) in a dose dependent manner. The lowest minimum inhibitory concentration (MIC) of the extracts on the test organisms were demonstrated against S. aureus, P.mirabilis, L.monocytogenes, E. coli and S. typhi and the highest MIC was exhibited against P.aeruginosa. Ethulia conyzoides has broad spectrum antibacterial activities and it is a potential source of new classes of antibiotics that could be useful for treating infectious disease.

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