Cell cycle distribution response of human lymph node prostate carcinoma (LNCaP) cell line to selected diet-derived agents

Chinyere Ibeawuchi-Onuoha, Ifeoma Anyiam

Abstract


Decline in prostate cancer incidence and mortality rates can be achieved with the adoption of healthier lifestyles and chemoprevention. The use of some notable diet-derived agents has been advocated based on cultural inclinations and basic scientific outcomes. However significant advances in chemoprevention can be made chiefly through the comprehensive knowledge of these naturally-sourced compounds. Alterations to the cell cycle mechanism of LNCaP cell lines were investigated for responses to selected doses of curcumin, 3,3’- diindolylmethane (DIM) and epigallocatechin-gallate (EGCG). The flow cytometry technique in combination with propidium iodide (PI) staining was used for the study. Results obtained reveal different levels and occurrences of cell cycle arrest. The under-studied diet-derived agents possess the capabilities of inhibiting prostate cancer growth and survival by inducing cell cycle arrest although at varying degrees, which needs further investigations.


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