Effect of ethanol extract of Corchorus olitorus leaf on glucose level and antioxidant enzymes of Streptozotocin-induced hyperglycemic rat

Kingsley Omeje, Tobechukwu Ezike, Tobechukwu Ezike, Henry Omeje, Benjamin Ezema

Abstract


In this study, we investigated the effect of ethanolic extract of Corchorus olitorus to ascertain its anti-hyperglycemic property. Diabetes was induced intraperitorially, by injecting streptozotocin with a single dose of 50mg/kg body weight. After oral administration of extract for thirty (30) days, the animals were fasted overnight, anaesthetized with chloroform and blood sample collected from the retro-bulbar plexus of the medial canthus of the eye. The plant extract has high safety index as no toxicity or mortality was record at after the oral administration 5000mg/kg body weight of the ethanol extract. Also, the results of this study shows that the extract has a dose dependent effect on the blood glucose level which was statistically significant (p<0.05) when compared to the untreated group with a glucose reduction values of 200.6 ± 1.11mg/ml and 98.6 ± 0.76 for 200 mg/kg body weight. Similarly, the extract significantly decreased (p>0.05) the activities of catalase, superoxide dismutase and liver function enzymes assayed (alanine aminotransferase, ALT, alkaline phosphatase, ALP, aspartate aminotransferase, AST) when compared to the untreated groups. The results indicate that the extract possesses anti-hyperglycemic effect, hence could be used in the management of diabetes mellitus.


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