Testicular toxicity: ameliorative role of Jatropha gossypifolia leaves and alpha-lipoic acid in male rats.

Opeyemi Faokunla, Oluseyi Akinloye, Regina Ugbaja, Abideen Adeogun


Exposure to pesticides, especially cypermethrin (Cyp) which is one of the most widely used synthetic pyrethroids, has been associated with decline in semen quality and increased risk of male infertility. This study was targeted at investigating the possible ameliorative role of the methanolic extract of Jatropha gossypifolia (JG) leaves and alpha-lipoic acid against testicular/spermatozoal aberrations induced by cypermethrin exposure in rats. Eight groups of seven male wistar rats each were treated orally for 28 days: control, 20 mg/kg body weight (b.wt) of Cyp, Cyp+JG(50 mg/kg b.wt), Cyp+JG(100 mg/kg b.wt), Cyp+α-LA(50 mg/kg b.wt), JG(50 mg/kg b.wt), JG(100 mg/kg b.wt) and α-LA(50 mg/kg b.wt). Results from this study showed that cypermethrin exposure significantly decreased the livability of spermatozoans (15.09%) and increased the percentage of spermatozoans with morphological aberrations (153.40%). The plasma fructose concentration was also significantly reduced (80.89%) by the administration of cypermethrin. The testicular antioxidant status was also significantly altered after cypermethrin exposure.  In addition, there was a significant increase in the lipid profile (triglycerides, 96.46%; cholesterol, 64.99%; and phospholipids, 132.94%) of the testes after cypermethrin administration when compared to control. Co-administration with the doses of the methanolic leaf extract of the Jatropha gossypifolia significantly reversed these alterations. With further studies, Jatropha gossypifolia plant could be a possible remedy for the treatment of reproductive dysfunctions.

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