Antidiabetic activity of methanol root extract of Aristolochia bracteolata L. (Aristolochiaceae) on alloxan induced diabetic rats

Idayat Gbadamosi, Akindele Adeyi, Olawale Owoeye

Abstract


This study investigated the hypoglycaemic activity of methanolic root extract of Aristolochia bracteolata in alloxan-induced diabetic rats. Thirty male albino rats weighing between 120-150g divided into six groups of five rats each were used for the study. Group 1 served as normal control while Group 2, 3, 4 and 5 were induced with 150mg/kg alloxan monohydrate dissolved in 0.9% sterile saline and group 6 served as the extract control. Group 2, 3 and 4 were treated with 100, 300mg/kg of the plant extract and 10mg/kg of glibenclamide respectively for seven days. Group 5 was not treated post induction and served as the diabetic control group. Induction of alloxan increased blood glucose level, reduced the haematological parameters and increased the biochemical enzymes in the untreated group. However, treatment with the plant extract and glibenclamide caused marked decreased in the blood glucose level and improved the heamatological indices. The results further showed a marked decrease in ALT, AST and ALP activity in the treatment groups when compared with the positive control group. These findings showed that A. bracteolata possess potent antidiabetic properties and beneficial in the management of Type 1 diabetes.

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